vicissitude

A change or variation.

A usually unforeseen change in circumstance or experience that affects one’s life, especially in a trying way: synonym: difficulty.

The quality of being changeable; mutability.

Regular change or succession of one thing to another; alternation.

A passing from one state or condition to another; irregular change; revolution; mutation: as, the vicissitudes of fortune.

Regular change or succession from one thing to another; alternation; mutual succession; interchange.

Irregular change; revolution; mutation.

Changing conditions of fortune in one’s life; life’s ups and downs.

Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange.